Syntheses of model oligosaccharides of biological significance. X. Syntheses and NMR and mass spectral analysis of trideuteriomethyl di-3,6-O-(4-O-β-D-galactopyranosyl-2-acetamido-2-deoxy-β-D-glucopyranosyl)-β-D-galactopyranoside: the I antigen branchpoint penta- and tetrasaccharides and a related trisaccharide

DOI	Trouver le DOI : https://doi.org/10.1139/v90-147
Auteur	Rechercher : Whitfield, Dennis M.; Rechercher : Pang, Henrianna; Rechercher : Carver, Jeremy P.; Rechercher : Krepinsky, Jiri J.
Format	Texte, Article
Résumé	As part of our studies of complex oligosaccharides, in particular their three-dimensional structure, we have synthesized the antigen I branchpoint penta- and tetrasaccharides. The unbranched trisaccharide 3D was also synthesized, and its derivative 3B served as the intermediate for the synthesis of higher oligosaccharides. NMR spectra of major intermediates as well as of the final oligosaccharides were completely assigned. Mass spectra of the synthetic intermediates and the final oligosaccharides were analyzed and compared with those of a similar group of oligosaccharides containing L-fucose, N-acetyl-D-glucosamine, and D-galactose. Certain observations were made that could be utilized in the interpretation of mass spectra for the structural determination of protected oligosaccharides during the synthesis. Keywords: oligosaccharide synthesis, I antigen, carbohydrate mass spectrometry, carbohydrate NMR spectrometry, Gal-GlcNAc oligomers.
Date de publication	1990-06-01
Dans	Canadian Journal of Chemistry 68, nº 6 : 942–952.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro du CNRC	WHITFIELD1990
Numéro NPARC	9358505
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	9f1dd13f-e0cb-40c9-a290-81ee2fbcf11c
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-03-17

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