Functional cooperation among human IgG-specific murine monoclonal antibodies for the detection of weak blood group antibodies in routine agglutination tests

DOI	Trouver le DOI : https://doi.org/10.1111/j.1423-0410.1993.tb02526.x
Auteur	Rechercher : Lauren, St Mark; Rechercher : Marcil, Anne; Rechercher : Verrette, Sylvain; Rechercher : Lemieux, Dr. R
Format	Texte, Article
Sujet	agglutination tests; antibodies, anti-idiotypic; antibodies, monoclonal; binding, competitive; blood group antigens; blood grouping and crossmatching; diagnostic tests, routine; epitopes; female; immunoglobulin g; immunoglobulin isotypes; isoantibodies; mice; mice, inbred BALB C; species specificity
Résumé	Seven monoclonal antibodies (MAbs) selected from a large panel of human IgG-specific murine MAbs were characterized serologically and studied for their ability to cooperate in routine antihuman globulin agglutination tests. In binding inhibition experiments, three of these MAbs were shown to bind simultaneously to immobilized human IgG molecules. Cooperation among these MAbs increased significantly the capacity of the individual MAbs to agglutinate red cells sensitized with weak blood group antibodies. These results demonstrate the usefulness of selected MAb blending for the preparation of potent antihuman IgG reagents from murine monoclonal antibodies.
Date de publication	1993
Dans	Vox Sanguinis 64, nº 2 (1993) : 99–105.
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	12328124
Exporter la notice	Exporter en format RIS
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Identificateur de l’enregistrement	9c97d304-2f29-44bc-98a2-a0c9638b2063
Enregistrement créé	2009-09-10
Enregistrement modifié	2020-04-24

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Date de modification :: 2026-07-22