| Téléchargement | - Voir la version finale : Modern sensor tools and techniques for monitoring, controlling, and improving cell culture processes (PDF, 1.8 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.3390/pr10020189 |
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| Auteur | Rechercher : Reyes, Sebastian Juan1; Rechercher : Durocher, Yves1Identifiant ORCID : https://orcid.org/0000-0002-2268-4111; Rechercher : Pham, Phuong Lan1Identifiant ORCID : https://orcid.org/0000-0002-2390-9730; Rechercher : Henry, Olivier |
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| Affiliation | - Conseil national de recherches Canada. Thérapeutique en santé humaine
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| Bailleur de fonds | Rechercher : Natural Sciences and Engineering Research Council; Rechercher : National Research Council Canada |
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| Format | Texte, Article |
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| Sujet | bioprocess; cell culture; monitoring; PAT; sensors; smart biomanufacturing; soft-sensor; spectroscopy |
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| Résumé | The growing biopharmaceutical industry has reached a level of maturity that allows for the monitoring of numerous key variables for both process characterization and outcome predictions. Sensors were historically used in order to maintain an optimal environment within the reactor to optimize process performance. However, technological innovation has pushed towards on-line in situ continuous monitoring of quality attributes that could previously only be estimated offline. These new sensing technologies when coupled with software models have shown promise for unique fingerprinting, smart process control, outcome improvement, and prediction. All this can be done without requiring invasive sampling or intervention on the system. In this paper, the state-of-the-art sensing technologies and their applications in the context of cell culture monitoring are reviewed with emphasis on the coming push towards industry 4.0 and smart manufacturing within the biopharmaceutical sector. Additionally, perspectives as to how this can be leveraged to improve both understanding and outcomes of cell culture processes are discussed. |
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| Date de publication | 2022-02 |
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| Maison d’édition | Elsevier |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Identificateur | pr10020189 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 9b8dd80d-153d-4bf6-8cfb-ea733449c4e7 |
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| Enregistrement créé | 2024-02-27 |
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| Enregistrement modifié | 2025-11-03 |
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