Self-assembled poloxamer-legumin/vicilin nanoparticles for the nanoencapsulation and controlled release of folic acid

Par Conseil national de recherches du Canada

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DOI	Trouver le DOI : https://doi.org/10.1016/j.ijbiomac.2024.131646
Auteur	Rechercher : Fang, Changhao; Rechercher : Kanemaru, Karen; Rechercher : Carvalho, Wildemar S.P.; Rechercher : Fruehauf, Krista R.; Rechercher : Zhang, Sunshine; Rechercher : Das, Prem P.¹Identifiant ORCID : https://orcid.org/0000-0001-8044-0425; Rechercher : Xu, Caishuang¹; Rechercher : Lu, Yuping¹; Rechercher : Rajagopalan, Nandhakishore¹; Rechercher : Kulka, Marianna²; Rechercher : Makeiff, Darren A.²; Rechercher : Serpe, Michael J.
Affiliation	Conseil national de recherches Canada. Développement des cultures et des ressources aquatiques Conseil national de recherches Canada. Quantique et nanotechnologies
Bailleur de fonds	Rechercher : National Research Council Canada
Format	Texte, Article
Sujet	nanoencapsulation; legumin and vicilin; fava beans; folic acid; drug delivery; self-assembly
Résumé	Plant-based food proteins are a promising choice for the preparation of nanoparticles (NPs) due to their high digestibility, low cost, and ability to interact with various compounds and nutrients. Moreover, nanoencapsulation offers a potential solution for protecting nutrients during processing and enhancing their bioavailability. This study aimed to develop and evaluate nanoparticles (NPs) based on legumin/vicilin (LV) proteins extracted from fava beans, with the goal of encapsulating and delivering a model nutraceutical compound, folic acid (FA). Specifically, NPs were self-assembled from LV proteins extracted from commercially available frozen fava beans using a pH-coacervation method with poloxamer 188 (P188) and chemically cross-linked with glutaraldehyde. Microscopy and spectroscopy studies were carried out on the empty and FA-loaded NPs in order to evaluate the particle morphology, size, size distribution, composition, mechanism of formation, impact of FA loading and release behavior. In vitro studies with Caco-2 cells also confirmed that the empty and FA-loaded nanoparticles were non-toxic. Thus, the LV-NPs are good candidates as food additives for the delivery and stabilization of nutrients as well as in drug delivery for the controlled release of therapeutics.
Date de publication	2024-04-16
Maison d’édition	Elsevier
Licence	Creative Commons, Attribution - Pas d’Utilisation Commerciale 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/deed.fr
Dans	International Journal of Biological Macromolecules 268, nº P2, 131646 (mai 2024).
Langue	anglais
Publications évaluées par des pairs	Oui
Identificateur	S0141813024024516
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	9646b737-cdbf-4398-8c1b-dcf8eae7772d
Enregistrement créé	2024-06-07
Enregistrement modifié	2025-11-03

Date de modification :: 2025-12-13