Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells

DOI	Trouver le DOI : https://doi.org/10.1016/j.bbrc.2008.04.119
Auteur	Rechercher : Chakravarthy, Balu¹; Rechercher : Rashid, Amal¹; Rechercher : Brown, Leslie¹; Rechercher : Tessier, Luc¹; Rechercher : Kelly, John¹; Rechercher : Ménard, Michel¹
Affiliation	Conseil national de recherches Canada. Institut des sciences biologiques du CNRC
Format	Texte, Article
Sujet	Gap-43; MAP-2; protein–protein interaction
Résumé	Gap-43 (B-50, neuromodulin) is a presynaptic protein implicated in axonal growth, neuronal differentiation, plasticity, and regeneration. Its activities are regulated by its dynamic interactions with various neuronal proteins, including actin and brain spectrin. Recently we have shown that Gap-43 co-localizes with an axonal protein DPYSL-3 in primary cortical neurons. In the present study we provide evidence that Gap-43 co-localizes and potentially interacts with microtubule-associated protein MAP-2 in adult and fetal rat brain, as well as in primary neuronal cultures. Our studies suggest that this interaction may be developmentally regulated.
Date de publication	2008-05-01
Maison d’édition	Elsevier
Dans	Biochemical and Biophysical Research Communications 371, nº 4 : 679–683.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	CHAKRAVARTHY2008
Numéro NPARC	9358348
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	91814ebb-d7ee-44e3-87c6-5072fb2a4bca
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-04-15

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Date de modification :: 2026-10-09