Hepatoprotective effect of Combretum quadrangulare and its constituents

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1248/bpb.23.456
Auteur	Rechercher : Banskota, Arjun Hari; Rechercher : Tezuka, Yasuhiro; Rechercher : Adnyana, I Ketut; Rechercher : Xiong, Quanbo; Rechercher : Hase, Koji; Rechercher : Tran, Kim Qui; Rechercher : Tanak, Ken; Rechercher : Saiki, Ikuo; Rechercher : Kadota, Shigetoshi
Format	Texte, Article
Sujet	Combretum quadrangulare; hepatoprotective effect; flavone, cycloartane-type triterpene; flavone C-glycoside
Résumé	The MeOH extract of leaves of Combretum quadrangulare showed significant hepatoprotective effect on D-galactosamin (D-GalN)/lipopolysaccharide (LPS)induced experimental liver injury in mice and on D-GalN/tumor necrosis factor-α (TNF-α)-induced cell death in primary cultured mouse hepatocytes. Phytochemical investigation led to the isolation of thirty cycloartane-type triterpenes together with betulinic acid, β-stitosterol, β-sitosterol glucoside, 4 flavones (34-37), and 3 flavone C-glucosides (38-40). These compounds showed various potencies of hepatoprotective effect on D-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes. Quadrangularol B (29), methyl quadrangularate I (33), kamatakenin (34), 5, 7, 4'-trihydroxy-3, 3'-dimethoxyflavone (35), 5, 4'-dihydroxy-3, 7, 3'-trimethoxyflavone (36) and isokaempferide (37) showed strong inhibitory effect on TNF-α-induced cell death with IC50 values of 34.3, 33.7, 13.3, 22.4, 13.4 and 22.8 μM, respectively, whereas clinically-used silibinin had an IC50 value of 39.6 μM and glycyrrhizin showed very weak inhibitory effect. Methyl quadarangularates A (30) and N (32), norquadrangularic acid B (31) and vitexin (40) also showed potent inhibition on TNF-α-induced cell death with IC50 values of 45.7, 89.3, 67.6 and 40.1 μM, respectively. The flavonoids and some of the cycloartane-type triterpenes appeared to be the hepatoprotective priniciples of the leaves of C. quadrangulare.
Date de publication	2000
Dans	Biological and Pharmaceutical Bulletin 23, nº 4 (2000) : 456–460.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	21275301
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Identificateur de l’enregistrement	79d12ea4-384c-4443-8121-58d577a6b103
Enregistrement créé	2015-06-04
Enregistrement modifié	2020-03-26

Date de modification :: 2024-11-08