Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice

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DOI	Trouver le DOI : https://doi.org/10.1186/s40168-017-0246-x
Auteur	Rechercher : Ryan, Paul M.; Rechercher : London, Lis E. E.; Rechercher : Bjorndahl, Trent C.¹; Rechercher : Mandal, Rupasri¹; Rechercher : Murphy, Kiera; Rechercher : Fitzgerald, Gerald F.; Rechercher : Shanahan, Fergus; Rechercher : Ross, R. Paul; Rechercher : Wishart, David S.¹; Rechercher : Caplice, Noel M.; Rechercher : Stanton, Catherine
Affiliation	Conseil national de recherches Canada. Nanotechnologie
Format	Texte, Article
Sujet	apo-E-deficient; atherosclerosis; cardiovascular disease; microbiome; metabolome
Résumé	There is strong evidence indicating that gut microbiota have the potential to modify, or be modified by the drugs and nutritional interventions that we rely upon. This study aims to characterize the compositional and functional effects of several nutritional, neutraceutical, and pharmaceutical cardiovascular disease interventions on the gut microbiome, through metagenomic and metabolomic approaches. Apolipoprotein-E-deficient mice were fed for 24 weeks either high-fat/cholesterol diet alone (control, HFC) or high-fat/cholesterol in conjunction with one of three dietary interventions, as follows: plant sterol ester (PSE), oat β-glucan (OBG) and bile salt hydrolase-active Lactobacillus reuteri APC 2587 (BSH), or the drug atorvastatin (STAT). The gut microbiome composition was then investigated, in addition to the host fecal and serum metabolome.
Date de publication	2017-03-13
Maison d’édition	BioMed Central
Dans	Microbiome 5, nº 1.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro NPARC	23003202
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	787f9c50-c4d7-48c8-9092-7ba855ddd9ef
Enregistrement créé	2018-05-07
Enregistrement modifié	2020-05-30

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Date de modification :: 2026-04-21