| Téléchargement | - Voir la version finale : Anisotropic permeability in deterministic lateral displacement arrays (PDF, 1.4 Mio)
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| Auteur | Rechercher : Vernekar, Rohan; Rechercher : Krüger, Timm; Rechercher : Loutherback, Kevin; Rechercher : Morton, Keith1; Rechercher : Inglis, David |
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| Affiliation | - Conseil national de recherches du Canada. Dispositifs médicaux
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| Format | Texte, Article |
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| Résumé | We investigate anisotropic permeability of microfluidic deterministic lateral displacement (DLD) arrays. A DLD array can achieve high-resolution bimodal size-based separation of micro-particles, including bioparticles such as cells. Correct operation requires that the fluid flow remains at a fixed angle with respect to the periodic obstacle array. We show via experiments and lattice-Boltzmann simulations that subtle array design features cause anisotropic permeability. The anisotropy, which indicates the array's intrinsic tendency to induce an undesired lateral pressure gradient, can lead to off-axis flows and therefore local changes in the critical separation size. Thus, particle trajectories can become unpredictable and the device useless for the desired separation duty. We show that for circular posts the rotated-square layout, unlike the parallelogram layout, does not suffer from anisotropy and is the preferred geometry. Furthermore, anisotropy becomes severe for arrays with unequal axial and lateral gaps between obstacle posts and highly asymmetrical post shapes. |
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| Date de publication | 2016-10-26 |
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| Maison d’édition | Cornell University Library |
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| Dans | |
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| Autre version | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23002041 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 5e60f1fb-d78c-47b9-8e8f-1a8504d20d90 |
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| Enregistrement créé | 2017-07-27 |
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| Enregistrement modifié | 2020-05-30 |
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