The effects of corticotrophin (ACTH1–24), cyclic AMP and TPA (12-0-tetradecanoyl phorbol-13-acetate) on DNA replication and proliferation of primary rabbit adrenocortical cells in a synthetic medium

DOI	Trouver le DOI : https://doi.org/10.1016/S0006-291X(87)80274-7
Auteur	Rechercher : Menapace, L.; Rechercher : Armato, U.; Rechercher : Whitfield, James
Format	Texte, Article
Résumé	ACTH1–24 stimulated the parenchymal cells in cultures of rat adrenal cortex in serum-free synthetic HiWoBa 2000 medium to replicate DNA, enter mitosis and divide. But ACTH's principal mediator, cyclic AMP, was not a complete mitogen: the adenylate cyclase-stimulating cholera toxin and dibutyryl cyclic AMP stimulated parenchymal cells to replicate DNA but not to enter mitosis. Thus, there must have been an additional mediator of the response to ACTH1–24 that enabled the parenchymal cells to enter mitosis. This additional mediator might have been protein kinase C because a protein kinase C activator and cyclic AMP elevator, TPA, stimulated the adrenocortical parenchymal cells to replicate DNA, enter mitosis and divide.
Date de publication	1987-11-13
Maison d’édition	Elsevier
Dans	Biochemical and Biophysical Research Communications 148, nº 3 : 1295–1303.
Langue	anglais
Publications évaluées par des pairs	Oui
Numéro du CNRC	MENAPACE1987
Numéro NPARC	9386170
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	53b047a3-ec55-4b5f-8a7b-3fec63a5b79d
Enregistrement créé	2009-07-10
Enregistrement modifié	2020-03-17

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