Part 3. A Novel Stereocontrolled, In Situ, Solution- and Solid-Phase, Aza Michael Approach for High-Throughput Generation of Tetrahydroaminoquinoline-Derived Natural-Product-like Architectures

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DOI	Trouver le DOI : https://doi.org/10.1021/cc060059n
Auteur	Rechercher : Prakesch, Michael; Rechercher : Srivastava, Stuti; Rechercher : Leek, Donald M.¹; Rechercher : Arya, Prabhat¹
Affiliation	Conseil national de recherches du Canada. Institut Steacie des sciences moléculaires du CNRC
Format	Texte, Article
Résumé	With the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.
Date de publication	2006-09-11
Dans	Journal of Combinatorial Chemistry 8, nº 5 (11 septembre 2006) : 762–773.
Numéro NPARC	12339184
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Identificateur de l’enregistrement	51f42bf7-9f74-4405-a778-36652c06c3f7
Enregistrement créé	2009-09-11
Enregistrement modifié	2020-04-22