| DOI | Trouver le DOI : https://doi.org/10.1089/ten.tec.2024.0083 |
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| Auteur | Rechercher : Li, Ying Betty1, 2Identifiant ORCID : https://orcid.org/0000-0002-1560-8866; Rechercher : Rukhlova, Marina1; Rechercher : Zhang, Dongling1; Rechercher : Nhan, Jordan3Identifiant ORCID : https://orcid.org/0000-0002-7179-8588; Rechercher : Sodja, Caroline1; Rechercher : Bedford, Erin4; Rechercher : St-Pierre, Jean-Philippe5; Rechercher : Jezierski, Anna1, 3 |
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| Affiliation | - Conseil national de recherches Canada. Thérapeutique en santé humaine
- Carleton University. Department of Systems and Computer Engineering
- University of Ottawa. Department of Chemical and Biological Engineering
- Aspect Biosystems Ltd.
- University of Ottawa, Ottawa. Department of Chemical and Biological Engineering
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| Format | Texte, Article |
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| Résumé | In the advent of tissue engineering and regenerative medicine, the demand for innovative approaches to biofabricate complex vascular structures is increasing. We describe a single-step 3D bioprinting method leveraging Aspect Biosystems RX1 technology, which integrates the crosslinking step at a flow-focusing junction, to biofabricate immortalized adult rat brain endothelial cell (SV-ARBEC)-encapsulated alginate–collagen type I hydrogel rings. This single-step biofabrication process involves the strategic layer-by-layer assembly of hydrogel rings, encapsulating SV-ARBECs in a spatially controlled manner while optimizing access to media and nutrients. The spatial arrangement of the SV-ARBECs within the rings promotes spontaneous angiogenic network formation and the constrained deposition of cells within the hydrogel matrix facilitates tissue-like organized vascular-like network development. This approach provides a platform that can be adapted to many different endothelial cell types and leveraged to better understand the mechanisms driving angiogenesis and vascular-network formation in 3D bioprinted constructs supporting the development of more complex tissue and disease models for advancing drug discovery, tissue engineering, and regenerative medicine applications. |
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| Date de publication | 2024-07-17 |
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| Maison d’édition | Mary Ann Liebert |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 50a8f325-20fc-49d0-8c5c-81734b5e7628 |
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| Enregistrement créé | 2024-09-13 |
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| Enregistrement modifié | 2024-09-13 |
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