| DOI | Trouver le DOI : https://doi.org/10.1021/ja954030r |
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| Auteur | Rechercher : Valgimigli, L.; Rechercher : Ingold, K. U.1; Rechercher : Lusztyk, J. |
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| Affiliation | - Conseil national de recherches du Canada
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| Format | Texte, Article |
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| Sujet | alpha tocopherol derivative; trolox c; antioxidant activity; in vitro study |
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| Résumé | Rate constants for hydrogen atom abstraction from two water-soluble α-tocopherol (α-TOH, vitamin E) analogues by tert-butoxyl radicals have been measured at room temperature in four solvents, including water. The results imply that H-atom abstraction from α-TOH is 3.9 times slower in water than in benzene and yield a 'reliable' Kamlet-Taft β solvent parameter for water of 0.31. Literature rate constants for H-atom abstraction by peroxyl radicals from α-TOH in SDS micelles and in phospholipid micelles are, respectively, about 100 and 1000 times lower than in styrene. Since only a small fraction of the observed rate diminution can be attributed to hydrogen bonding of α-TOH to water it is concluded that in these heterogeneous systems much of the α-TOH is physically inaccessible to the attacking radicals. Whether this is also true for α-TOH in the biological membranes in living animals remains to be determined. |
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| Date de publication | 1996 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21276501 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 496231f8-1ffe-47b8-857d-5b9343adb5d0 |
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| Enregistrement créé | 2015-10-13 |
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| Enregistrement modifié | 2020-03-20 |
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