Robust and flexible electrochemical lactate sensors for sweat analysis based on nanozyme-enhanced electrode

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DOI	Trouver le DOI : https://doi.org/10.1016/j.biosx.2024.100455
Auteur	Rechercher : Li, Pei; Rechercher : Kalambate, Pramod K.; Rechercher : Harris, Kenneth D.¹; Rechercher : Jemere, Abebaw B.¹; Rechercher : Tang, Xiaowu (Shirley)Identifiant ORCID : https://orcid.org/0000-0002-9734-4365
Affiliation	Conseil national de recherches Canada. Nanotechnologie
Bailleur de fonds	Rechercher : Waterloo Institute for Nanotechnology Mike and Ophelia Lazaridis Quantum-Nano Centre; Rechercher : National Research Council Canada
Format	Texte, Article
Sujet	lactate sensor; electrochemical sensor; sweat sample; nanozyme; NiO; glancing angle deposition (GLAD)
Résumé	In this work, nickel oxide (NiO) nanostructures deposited by glancing angle deposition (GLAD) are fabricated to achieve highly specific catalytic electrooxidation of lactate, replacing the natural enzyme lactate oxidase for electrochemical detection of lactate in sweat. GLAD NiO electrodes exhibit high sensitivity (412 μA mM⁻¹ cm⁻²), wide linear detection range (1–45 mM), low detection limit (3 μM), and excellent specificity in artificial sweat samples. The unique microporous structure of the GLAD NiO electrodes, combined with their high surface area, high catalytic activity, and excellent conductivity, enhance the performance of the sensor and demonstrate their exceptional effectiveness in the sensitive detection of lactate. In-house fabricated gold counter, and stable solid-state Ag/AgCl reference electrodes, all fabricated on a flexible PET substrate along with the GLAD NiO working electrode, demonstrate performance comparable to commercial Pt auxiliary and Ag/AgCl (1M KCl) reference electrodes in lactate detection, along with outstanding flexibility, tested at various radii of curvature (15 mm, 7.5 mm, and 5 mm). The durable and long-lasting GLAD NiO electrode chips overcome numerous challenges in transport, storage, and operation, paving the way for the development of wearable lactate sensors that can detect lactate levels in sweat.
Date de publication	2024-02-15
Maison d’édition	Elsevier
Licence	Creative Commons, Attribution - Pas d’Utilisation Commerciale – Pas de Modification 4.0 Générique (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr
Dans	Biosensors and Bioelectronics: X 17, nº C, 100455 (avril 2024).
Langue	anglais
Publications évaluées par des pairs	Oui
Identificateur	S2590137024000190
Numéro du CNRC	NRC-NANO 299
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	47a0b375-f58d-4d10-9a36-8ad7910ce10c
Enregistrement créé	2024-03-07
Enregistrement modifié	2025-11-03

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Date de modification :: 2026-08-13