| Téléchargement | - Voir la version finale : Phaseic acid: an endogenous and reversible inhibitor of glutamate receptors in mouse brain (PDF, 8.4 Mio)
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| DOI | Trouver le DOI : https://doi.org/10.1074/jbc.M116.756429 |
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| Auteur | Rechercher : Hou, Sheng T.1; Rechercher : Jiang, Susan X.1; Rechercher : Zaharia, L. Irina2; Rechercher : Han, Xiumei2; Rechercher : Benson, Chantel L.2; Rechercher : Slinn, Jacqueline1; Rechercher : Abrams, Suzanne R.2 |
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| Affiliation | - Conseil national de recherches du Canada. Thérapeutique en santé humaine
- Conseil national de recherches du Canada. Développement des cultures et des ressources aquatiques
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| Format | Texte, Article |
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| Sujet | phaseic acid; abscisic acid; UPLC/MS/MS; endothelial cells; choroid plexus; cerebrospinal fluid; cerebral ischemia |
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| Résumé | Phaseic acid (PA) is a phytohormone regulating important physiological functions in higher plants. Here, we show the presence of naturally occurring (-)-PA in mouse and rat brains. (-)-PA is exclusively present in the choroid plexus and the cerebral vascular endothelial cells. Purified (-)-PA has no toxicity and protects cultured cortical neurons against glutamate toxicity through reversible inhibition of glutamate receptors. Focal occlusion of the middle cerebral artery (MCAO) elicited a significant induction in (-)-PA expression in the CSF, but not in the peripheral blood. Importantly, (-)-PA induction only occurred in the penumbra area, indicting a protective role of PA in the brain. Indeed, elevating (-)-PA level in the brain reduced ischemic brain injury, while reducing (-)-PA level using a monoclonal antibody against (-)-PA increased ischemic injury. Collectively, these studies showed for the first time that (-)-PA is an endogenous neuroprotective molecule capable of reversible inhibiting glutamate receptors during ischemic brain injury. |
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| Date de publication | 2016-11-18 |
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| Maison d’édition | American Society for Biochemistry and Molecular Biology |
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| Licence | |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 23001033 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 3d585ba4-1b44-4f27-9795-6bb4efa62f4e |
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| Enregistrement créé | 2016-12-01 |
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| Enregistrement modifié | 2021-04-26 |
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