Bovine dendritic cell activation, T cell proliferation and antibody responses to foot-and-mouth disease, is similar with inactivated virus and virus like particles

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DOI	Trouver le DOI : https://doi.org/10.3389/fvets.2020.00594
Auteur	Rechercher : Quattrocchi, Valeria; Rechercher : Bidart, Juan; Rechercher : Mignaqui, Ana Clara; Rechercher : Ruiz, Vanesa; Rechercher : Ferella, Alejandra; Rechercher : Langellotti, Cecilia; Rechercher : Gammella, Mariela; Rechercher : Ferraris, Sergio; Rechercher : Carrillo, Jorge; Rechercher : Wigdorovitz, Andres; Rechercher : Durocher, Yves¹; Rechercher : Cardillo, Sabrina Beatriz; Rechercher : Charleston, Bryan; Rechercher : Zamorano, Patricia Inés
Affiliation	Conseil national de recherches Canada. Thérapeutique en santé humaine
Format	Texte, Article
Sujet	FMDV; empty capsids; dendritic cells; bovine; A/ARG/2001
Résumé	Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals that causes severe economic losses in the livestock industry. Currently available vaccines are based on the inactivated FMD virus (FMDV). Although inactivated vaccines have been effective in controlling the disease, they have some disadvantages. Because of these disadvantages, investigations are being made to produce vaccines in low containment facilities. The use of recombinant empty capsids (also referred as Virus Like Particles, VLPs) has been reported to be a promising candidate as a subunit vaccine because it avoids the use of virus in the vaccine production and conserves the conformational epitopes of the virus. Mignaqui and collaborators have produced recombinant FMDV empty capsids from serotype A/ARG/2001 using a scalable technology in mammalian cells that elicited a protective immunity against viral challenge in a mouse model. However, further evaluation of the immune response elicited by these VLPs in cattle is required. In the present work we compare the effect that VLPs or inactivated FMDV has on bovine dendritic cells and the humoral response elicited in cattle after a single vaccination.
Date de publication	2020-09-30
Maison d’édition	Frontiers Media SA
Licence	Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/deed.fr
Dans	Frontiers in Veterinary Science 7, 594.
Note	yes
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	3911c0e4-23de-4ae9-90ad-97fae2c90778
Enregistrement créé	2021-04-14
Enregistrement modifié	2021-09-21

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