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7-Demethylsuberosin and osthenol as intermediates in furanocoumarin biosynthesis

DOITrouver le DOI : https://doi.org/10.1016/0031-9422(73)80558-8
AuteurRechercher : ; Rechercher : 1
Affiliation
  1. Conseil national de recherches du Canada. Laboratoire régional des prairies
FormatTexte, Article
SujetConium maculatum; Heracleum lanatum; Ruta graveolens; Coronilla glauca; coumarins; furanocoumarins; biosynthesis; 7-demethylsuberosin; osthenol
Résumé
¹⁴C-Labelled 7-demethylsuberosin (DMS) was a precursor of linear furanocoumarins in Conium maculatum and Heracleum lanatum (Umbelliferae), and in Ruta graveolens (Rutaceae), but not in Coronilla glauca (Leguminosae). Trapping experiments with ¹⁴C-umbelliferone over 3- to 24-hr periods revealed that DMS is rapidly metabolized, and that in short experiments its specific activity relative to the linear furano- coumarins′ is that of an intermediate. The specific activity of umbelliferone exhibited anomalies attributed to pool compartmentation. Analogous but less extensive experiments established that osthenol is an intermediate in angular furanocoumarin biosynthesis, but is much less rapidly metabolized than DMS. No significant incorporation into furanocoumarins of ¹⁴C from labelled l-valine, l-leucine, acetate, 2,3-di-hydroxyisovaleric acid, senecioic acid, isopentenylpyrophosphate, or mevalonate could be demonstrated. A synthesis of [1-¹⁴C]2,3-dihydroxyisovaleric acid is described.
Date de publication
Maison d’éditionElsevier
Pergamon Press
Dans
  • Phytochemistry 12, nº 6 (juin 1973) : 1315–1324.
Langueanglais
Publications évaluées par des pairsOui
Identificateur0031942273805588
NRCC-13735
Exporter la noticeExporter en format RIS
Signaler une correctionSignaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement3388a276-fe6a-4bd4-bfc0-7345206b60e2
Enregistrement créé2023-10-11
Enregistrement modifié2023-10-11

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