| DOI | Trouver le DOI : https://doi.org/10.3390/cells4030253 |
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| Auteur | Rechercher : Whitfield, James F.1; Rechercher : Chiarini, Anna; Rechercher : Dal Prà, Ilaria; Rechercher : Armato, Ubaldo; Rechercher : Chakravarthy, Balu1 |
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| Affiliation | - Conseil national de recherches Canada. Thérapeutique en santé humaine
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| Format | Texte, Article |
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| Sujet | adult neurogenesis; Alzheimer’s disease; amyloid-β; amyloid-β oligomers; ciliary LepRb; dentate gyrus; hippocampus; hyperphosphorylated tau; leptin; memory formation; p75NTR; somatostatin receptor |
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| Résumé | Dentate-gyral granule cells in the hippocampus plus dentate gyrus memory-recording/retrieving machine, unlike most other neurons in the brain, are continuously being generated in the adult brain with the important task of separating overlapping patterns of data streaming in from the outside world via the entorhinal cortex. This “adult neurogenesis” is driven by tools in the mature granule cell’s cilium. Here we report our discovery of leptin’s LepRb receptor in this cilium. In addition, we discuss how ciliary LepRb signaling might be involved with ciliary p75NTR and SSTR3 receptors in adult neurogenesis and memory formation as well as attenuation of Alzheimer’s neuropathology by reducing the production of its toxic amyloid-β-derived drivers. |
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| Date de publication | 2015-07-13 |
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| Dans | |
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| Langue | anglais |
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| Publications évaluées par des pairs | Oui |
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| Numéro NPARC | 21276085 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 2f450cf1-b163-4b3d-aa27-e2fc29176f77 |
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| Enregistrement créé | 2015-09-22 |
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| Enregistrement modifié | 2020-04-22 |
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