| DOI | Trouver le DOI : https://doi.org/10.1016/j.bmc.2008.09.025 |
|---|
| Auteur | Rechercher : Prakesch, Michael1; Rechercher : Bijian, Krikor; Rechercher : Campagna-Slater, Valérie; Rechercher : Quevillon, Sophie1; Rechercher : Joseph, Reni1; Rechercher : Wei, Chang-Qing1; Rechercher : Sesmilo, Esther1; Rechercher : Reayi, Ayub1; Rechercher : Poondra, Rajamohan R.1; Rechercher : Barnes, Michael L.; Rechercher : Leek, Donald M.; Rechercher : Xu, Bin; Rechercher : Lougheed, Caroline; Rechercher : Schapira, Matthieu; Rechercher : Alaoui-Jamali, Moulay; Rechercher : Arya, Prabhat1 |
|---|
| Affiliation | - Conseil national de recherches Canada. Institut Steacie des sciences moléculaires du CNRC
|
|---|
| Format | Texte, Article |
|---|
| Sujet | natural products; natural product-like compounds; small-molecule chemical probes; diversity-oriented synthesis; focal adhesion kinase; signaling networks; cell migration; anti-cancer agents; docking |
|---|
| Résumé | Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken. |
|---|
| Date de publication | 2008-11 |
|---|
| Maison d’édition | Elsevier |
|---|
| Dans | |
|---|
| Langue | anglais |
|---|
| Publications évaluées par des pairs | Oui |
|---|
| Numéro NPARC | 12328434 |
|---|
| Exporter la notice | Exporter en format RIS |
|---|
| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
|---|
| Identificateur de l’enregistrement | 173e4574-524b-44f2-af7c-ab82af098ea8 |
|---|
| Enregistrement créé | 2009-09-10 |
|---|
| Enregistrement modifié | 2020-04-15 |
|---|
