Reagent-based, modular, tandem Michael approach for obtaining different indoline alkaloid-inspired polycyclic architectures

DOI	Trouver le DOI : https://doi.org/10.1021/cc800036w
Auteur	Rechercher : Brochu, Jean-Louis¹; Rechercher : Prakesch, Michael; Rechercher : Enright, Gary D.¹; Rechercher : Leek, Donald M.¹; Rechercher : Arya, Prabhat¹
Affiliation	Conseil national de recherches Canada. Institut Steacie des sciences moléculaires du CNRC
Format	Texte, Article
Résumé	A modular, reagent-based approach to obtain different indoline alkaloid-inspired, tetracyclic architectures is developed. With the use of TBSOTf as a Lewis acid, we report here a tandem Michael-based approach that led to the synthesis of a diastereomeric mixture of tetracyclic derivatives with two additional six-membered rings. By simply changing the Lewis acid to TMSOTf, we were able to obtain a different tetracyclic compound having additional functionalized 5- and 7-membered rings with complete stereocontrol.
Date de publication	2008-04-18
Dans	Journal of Combinatorial Chemistry 10, nº 3 (18 avril 2008) : 405–420.
Langue	anglais
Numéro NPARC	12328691
Exporter la notice	Exporter en format RIS
Signaler une correction	Signaler une correction (s'ouvre dans un nouvel onglet)
Identificateur de l’enregistrement	166e492e-4da0-4299-8413-384b3ee8621f
Enregistrement créé	2009-09-10
Enregistrement modifié	2020-04-15

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