Local mechanical and structural properties of healthy and diseased human ascending aorta tissue

Par Conseil national de recherches du Canada

DOI	Trouver le DOI : https://doi.org/10.1016/j.carpath.2008.01.001
Auteur	Rechercher : Choudhury, Nusrat; Rechercher : Bouchot, Olivier; Rechercher : Rouleau, Leonie; Rechercher : Tremblay, Dominique; Rechercher : Cartier, Raymond; Rechercher : Butany, Jagdish; Rechercher : Mongrain, Rosaire; Rechercher : Leask, Richard L.
Format	Texte, Article
Sujet	Aorta; Bicuspid; Mechanics; Hemodynamics; Elastic modulus
Résumé	Objective: This study investigates the mechanics and histology of healthy and dilated human ascending aortas (AA). The regional variation in mechanical response and tissue structure were compared. Methods: Rings of human AA from healthy (n=5), dilated tricuspid aortic valve (TAV, n=5), and dilated bicuspid aortic valve (BAV, n=6) patients were mechanically tested. Each aortic ring was sectioned into quadrants—anterior, posterior, medial (inner curvature) and lateral (outer curvature). Low- and high-stress elastic moduli were calculated from the equibiaxial stress strain curve to determine the local mechanical properties. Histological analysis was used to quantify the percent composition of elastin, collagen, and smooth muscle cells. Results: BAV tissue was thinnest and contained the largest percent composition of collagen. Both TAV and BAV tissue had significantly less elastin than healthy tissue. At low strain in the circumferential direction, TAV tissue was on average the least stiff. The elastic modulus was dependent on quadrant and tissue type but not direction (isotropic). Generally, the lateral quadrant tissue was the stiffest and the medial quadrant the least stiff. There were no apparent local variations in the tissue histology. Conclusions: Local variations in tissue thickness and mechanical properties were evident in all samples analyzed and may be linked to the type of aortic valve present.
Date de publication	2009-03-05
Dans	Cardiovascular Pathology 18, nº 2 (5 mars 2009) : 83–91.
Langue	anglais
Publications évaluées par des pairs	Oui
Publication du CNRC	Cette publication n’est pas du CNRC Ce sont des publications qui ont été rédigées par un auteur du CNRC, mais avant que celui-ci soit employé du CNRC.
Numéro NPARC	21276811
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Identificateur de l’enregistrement	0178ccc0-4ff1-4a05-a047-72386624a46c
Enregistrement créé	2015-10-22
Enregistrement modifié	2020-04-16

Date de modification :: 2026-01-18