| Auteur | Rechercher : Helander, A.; Rechercher : Kenne, L.; Rechercher : Oscarson, S.; Rechercher : Peters, T.; Rechercher : Brisson, J. |
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| Format | Texte, Article |
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| Sujet | analogs & derivatives; Carbohydrate Conformation; Carbohydrate Sequence; chemical; chemical shift; chemical synthesis; chemistry; Computer Simulation; CONFORMATIONAL; DIFFERENCE; Distance; GESA; GLOBAL; glycopeptide; Glycopeptides; glycoprotein; Glycoproteins; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mannose; Mannosides; MODEL; Models,Molecular; Molecular Sequence Data; Molecular Structure; MONTE CARLO; NMR; NOE; PROGRAM; REGION; Serine; SIGNALS; Simulation; SIMULATIONS; Support,Non-U.S.Gov't; Synthesis; theoretical; Threonine; yield |
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| Résumé | alpha-D-Mannopyranosyl and alpha-D-mannopyranosyl-(1----2)-alpha-D- mannopyranosyl linked to L-serine and L-threonine have been synthesised as model substances for the linkage region in certain O-linked glycoproteins. Metropolis Monte Carlo simulations were performed with a modified version of the GESA program, to yield theoretical NOEs and interatomic distances as ensemble-average values, and these were compared with results from steady-state NOE experiments. The NOEs were determined as ensemble-average and as global minimum values. NMR chemical shift differences, obtained for signals of the glycopeptides relative to those of the respective monomers, were interpreted in terms of short inter-residue atomic distances as found within the global minima, and on the basis of averaged distances derived from Monte Carlo simulations |
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| Date de publication | 1992-06-16 |
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| Dans | |
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| Langue | anglais |
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| Numéro du CNRC | HELANDER1992 |
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| Numéro NPARC | 9377435 |
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| Exporter la notice | Exporter en format RIS |
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| Signaler une correction | Signaler une correction (s'ouvre dans un nouvel onglet) |
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| Identificateur de l’enregistrement | 00484312-689c-4589-9ffa-da1825e43375 |
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| Enregistrement créé | 2009-07-10 |
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| Enregistrement modifié | 2020-04-24 |
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