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Chiral discrimination in the exchange of α-tocopherol stereoisomers between plasma and red blood cells

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1007/BF02540361
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Affiliation
  1. National Research Council of Canada
FormatText, Article
Subjectalpha tocopherol; animal cell; animal experiment; blood and hemopoietic system; diastereoisomer; drug distribution; erythrocyte; plasma; rat; Animal; Deuterium; Erythrocytes; Kinetics; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Structure-Activity Relationship; Support, Non-U.S. Gov't; Vitamin E
Abstract
The transport of 2 R,4′R, 8′R-α-tocopherol and 2 S,4′R,8′R-α-tocopherol from plasma into rat red blood cell membranes occurs with essentially no chiral discrimination. The previously demonstrated (10) preference of red blood cell membranes favoring 2 R,4′R,8′R-α-tocopherol over the 2 S,4′R, 8′R stereoisomer is shown to be due to better retention of the former compound, i.e., to preferential retention of natural vitamin E. © 1987 American Oil Chemists' Society.
Publication date
In
  • Lipids 22, no. 7 (1987): 469–473.
LanguageEnglish
Peer reviewedYes
NPARC number21276724
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Record identifierf9f6288b-b789-4e6f-a287-590371ffa917
Record created2015-10-13
Record modified2020-03-17
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