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Postischemic hypothermia protects against loss of agrin and SPARC from the vascular basement membrane in global cerebral ischemia

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1038/sj.jcbfm.9591524.0247
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Affiliation
  1. National Research Council of Canada. NRC Institute for Biological Sciences
FormatText, Address
Subjectblood-brain barrier; vascular basement membrane; cerebral ischemia; postischemic hypothermia
Abstract
Vascular basement membrane (BM) stabilizes brain vessels and inhibits endothelial cell cycle. Cerebral ischemia causes BM breakdown with the loss of structural BM components including collagens and laminins and subsequent endothelial cell activation and proliferation 1. However, the fate and role of BM proteoglycans and non-structural BM constituents, including SPARC (BM-40, osteonectin), in ischemic blood-brain barrier (BBB) pathophysiology remains unknown.
Publication date
In
  • Journal of Cerebral Blood Flow and Metabolism 25 (2005).
LanguageEnglish
NPARC number21275189
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Record identifierf9e9ce50-b082-4c44-a109-78fc2599f8dc
Record created2015-05-22
Record modified2020-03-03
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