Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides

DOI	Resolve DOI: https://doi.org/10.1016/j.bmcl.2008.01.061
Author	Search for: Kang, Tae-Souk; Search for: Jo, Hyang-Ok; Search for: Park, Woo-Kyu; Search for: Kim, Jong-Pyung; Search for: Konishi, Yasuo¹; Search for: Kong, Jae-Yang; Search for: Park, No-Sang; Search for: Jung, Young-Sik
Affiliation	National Research Council of Canada. NRC Biotechnology Research Institute
Format	Text, Article
Subject	pharmaceutical; synthesis
Abstract	A series of 3,5-dialkoxy-4-hydroxycinnamamides 6 and 7 was synthesized, and their antioxidant activity was assessed using the thiobarbituric acid reactive substance (TBARS) assay. Interestingly, cinnamamides with longer alkoxy groups on the C-3 and C-5 positions display enhanced inhibition, and most of the compounds in the series tested exhibit excellent lipid peroxidation inhibitory activities. Some cinamamides bearing hexyloxy or 2,6-di-tert-butyl-4-methyl phenol groups have submicromolar inhibitory activities
Publication date	2008
In	Bioorganic & Medicinal Chemistry Letters 18, no. 5: 1663–1667.
Language	English
Peer reviewed	Yes
NRC number	NRC-BRI-49571
NPARC number	3539059
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Record identifier	f9902e95-4960-4bd4-b973-7bfe8e9fcb28
Record created	2009-03-01
Record modified	2020-04-15