Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1038/sj.onc.1210667
Author	Search for: Ji, Y.¹; Search for: Shah, S.; Search for: Soanes, K.¹; Search for: Islan, M. N.; Search for: Hoxter, B.; Search for: Biffo, S.; Search for: Heslip, T.; Search for: Byers, S.
Affiliation	National Research Council of Canada. Aquatic and Crop Resource Development
Format	Text, Article
Abstract	Eukaryotic initiation factor 6 (eIF6), an essential protein important in ribosome biosynthesis and assembly, was identified as an interacting partner of the β-catenin C terminus in the yeast two-hybrid assay. Independent studies identified Drosophila eIF6 (DeIF6) in a genetic screen designed to detect new genes involved in the regulation of the Wnt/Wg (wingless) pathway. Ectopic expression of DeIF6 in wing discs results in a Wg phenotype. Expression of eIF6 in adenomatous polyposis coli (APC)-mutant colon cancer cells, which express high levels of active β-catenin, showed that eIF6 selectively inhibits the Wnt pathway at the level of β-catenin protein independently of proteasomal degradation. Incorporation of radiolabeled amino acids into β-catenin was selectively decreased in cells that overexpressed eIF6. A similar inverse relationship of the two proteins was observed in the APCmin/+ mouse intestine, in which β-catenin levels are very high. Taken together these data reveal a link between eIF6 and Wnt signaling, perhaps at the level of ribosome recycling on β-catenin mRNA
Publication date	2007-07-30
In	Oncogene 27 (30 July 2007): 755–762.
Language	English
Peer reviewed	Yes
NRC publication	This is a non-NRC publication "Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.
NRC number	1775
NPARC number	3538441
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Record identifier	f932caea-975c-46d6-88bc-6fd222fefe04
Record created	2009-03-01
Record modified	2020-05-10

Date modified:: 2024-07-27