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| DOI | Resolve DOI: https://doi.org/10.1016/j.isci.2023.107612 |
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| Author | Search for: Perera, Dilhan J.; Search for: Domenech, Pilar; Search for: Babuadze, George Giorgi; Search for: Naghibosadat, Maedeh; Search for: Alvarez, Fernando; Search for: Koger-Pease, Cal; Search for: Labrie, Lydia; Search for: Stuible, Matthew1; Search for: Durocher, Yves1; Search for: Piccirillo, Ciriaco A.; Search for: Lametti, André; Search for: Fiset, Pierre Olivier; Search for: Elahi, Seyyed Mehdy1; Search for: Kobinger, Gary P.; Search for: Gilbert, Rénald1; Search for: Olivier, Martin; Search for: Kozak, Robert; Search for: Reed, Michael B.; Search for: Ndao, MomarORCID identifier: https://orcid.org/0000-0002-9012-4212 |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Abstract | Recent publications have explored intranasal (i.n.) adenovirus-based (Ad) vaccines as an effective strategy for SARS-CoV-2 in pre-clinical models. However, the effects of prior immunizations and infections have yet to be considered. Here, we investigate the immunomodulatory effects of Mycobacterium bovis BCG pre-immunization followed by vaccination with an S-protein-expressing i.n. Ad, termed Ad(Spike). While i.n. Ad(Spike) retains some protective effect after 6 months, a single administration of BCG-Danish prior to Ad(Spike) potentiates its ability to control viral replication of the B.1.351 SARS-CoV-2 variant within the respiratory tract. Though BCG-Danish did not affect Ad(Spike)-generated humoral immunity, it promoted the generation of cytotoxic/Th1 responses over suppressive FoxP3⁺ TREG cells in the lungs of infected mice. Thus, this vaccination strategy may prove useful in limiting future pandemics by potentiating the long-term efficacy of mucosal vaccines within the context of the widely distributed BCG vaccine. |
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| Publication date | 2023-08-11 |
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| Publisher | Elsevier |
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| Licence | |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Identifier | S2589004223016899 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | f92e42df-d0b5-43cd-bd76-cec099f899ec |
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| Record created | 2024-05-28 |
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| Record modified | 2024-05-28 |
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