In vivo optical resolution photoacoustic microscopy using glancing angle-deposited nanostructured Fabry–Perot etalons

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DOIResolve DOI: https://doi.org/10.1364/OL.40.001350
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  1. National Research Council of Canada. National Institute for Nanotechnology
FormatText, Article
Journal titleOptics Letters
ISSN0146-9592
1539-4794
Volume40
Issue7
Pages1350–1353
Abstract
In this Letter, reflection-mode optical resolution photoacoustic microscopy (OR-PAM) using glancing angle-deposited (GLAD) nanostructured Fabry–Perot interferometers (FPI) for in vivo applications is reported. GLAD is a single-step physical vapor deposition (PVD) technique used to fabricate porous nanostructured thin films. Using titanium dioxide, a transparent semiconductor with a high refractive index (n=2.4), the GLAD technique can be employed to fabricate samples with tailored nano-porosity, refractive index periodicities, and high Q-factor reflectance spectra. The OR-PAM in vivo images of chorioallantoic membrane (CAM) of 5-day chicken embryo model are demonstrated. The phantom study shows lateral resolution and signal-to-noise ratio better than 7 μm and 35 dB, respectively. The sensitive GLAD FPI allows photoacoustic imaging down to a few-nJ pulse energy. To the best of our knowledge, this is the first time that a FPI-based reflection mode optical resolution photoacoustic imaging technique is demonstrated for in vivo applications.
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PublisherOSA Publishing
LanguageEnglish
Peer reviewedYes
NPARC number23001541
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Record created2017-03-03
Record modified2020-05-30
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