Isotope scrambling and error magnification in multiple-spiking isotope dilution

DOI	Resolve DOI: https://doi.org/10.1007/s00216-009-2619-x
Author	Search for: Meija, Juris¹ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: Ouerdane, Laurent¹; Search for: Mester, Zoltán¹ORCID identifier: https://orcid.org/0000-0002-2377-2615
Name affiliation	National Research Council of Canada. NRC Institute for National Measurement Standards
Format	Text, Article
Subject	isotope dilution; multiple spiking; uncertainty; error propagation; Monte Carlo; isotope scrambling
Abstract	The purpose of performing multiple spiking isotope dilution is to quantify interconverting substances. This feature has been utilized in analytical chemistry now for more than a decade. In this manuscript we show that the interconversion of analytes is inevitably accompanied by the gradual loss of information that can be extracted from the isotope patterns. Therefore, any corrections for analyte interconversion are performed at the expense of the precision of the obtained amount of interconverting analytes. Consequently, there is a natural, predictable limit to the applicability of multiple-spiking isotope dilution methods that can be summarized into a simple equation.
Publication date	2009-02-10
Publisher	Springer
In	Analytical and Bioanalytical Chemistry 394, no. 1: 199–205.
Language	English
Peer reviewed	Yes
NPARC number	23001628
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Record identifier	f1e1136e-df46-479e-9368-d40c3efcae20
Record created	2017-03-13
Record modified	2020-04-16