Isotope scrambling and error magnification in multiple-spiking isotope dilution

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1007/s00216-009-2619-x
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0002-2377-2615
Name affiliation
  1. National Research Council of Canada. NRC Institute for National Measurement Standards
FormatText, Article
Journal titleAnalytical and Bioanalytical Chemistry
ISSN1618-2642
1618-2650
Volume394
Issue1
Pages199–205
Subjectisotope dilution; multiple spiking; uncertainty; error propagation; Monte Carlo; isotope scrambling
Abstract
The purpose of performing multiple spiking isotope dilution is to quantify interconverting substances. This feature has been utilized in analytical chemistry now for more than a decade. In this manuscript we show that the interconversion of analytes is inevitably accompanied by the gradual loss of information that can be extracted from the isotope patterns. Therefore, any corrections for analyte interconversion are performed at the expense of the precision of the obtained amount of interconverting analytes. Consequently, there is a natural, predictable limit to the applicability of multiple-spiking isotope dilution methods that can be summarized into a simple equation.
Publication date
PublisherSpringer
LanguageEnglish
Peer reviewedYes
NPARC number23001628
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Record created2017-03-13
Record modified2020-04-16
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