Neurovascular unit: basic and clinical imaging with emphasis on advantages of ferumoxytol

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DOI	Resolve DOI: https://doi.org/10.1093/neuros/nyx357
Author	Search for: Netto, Joao Prola; Search for: Iliff, Jeffrey; Search for: Stanimirovic, Danica¹; Search for: Krohn, Kenneth A.; Search for: Hamilton, Bronwyn; Search for: Varallyay, Csanad; Search for: Gahramanov, Seymur; Search for: Daldrup-Link, Heike; Search for: D’esterre, Christopher; Search for: Zlokovic, Berislav; Search for: Sair, Haris; Search for: Lee, Yueh; Search for: Taheri, Saeid; Search for: Jain, Rajan; Search for: Panigrahy, Ashok; Search for: Reich, Daniel S.; Search for: Drewes, Lester R.; Search for: Castillo, Mauricio; Search for: Neuwelt, Edward A.
Affiliation	National Research Council of Canada. Human Health Therapeutics
Format	Text, Article
Subject	blood-brain barrier; imaging; neurovascular unit
Abstract	Physiological and pathological processes that increase or decrease the central nervous system's need for nutrients and oxygen via changes in local blood supply act primarily at the level of the neurovascular unit (NVU). The NVU consists of endothelial cells, associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymal cells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essential for interpretation of central nervous system physiology and pathology as revealed by conventional and advanced imaging techniques. This article reviews current strategies for interrogating the NVU, focusing on vascular permeability, blood volume, and functional imaging, as assessed by ferumoxytol an iron oxide nanoparticle.
Publication date	2017-07-21
Publisher	Lippincott, Williams & Wilkins
In	Neurosurgery.
Language	English
Peer reviewed	Yes
NPARC number	23002474
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Record identifier	eb02ac43-f522-473b-b85b-053c1c0ead37
Record created	2017-11-15
Record modified	2020-05-30

Date modified:: 2024-10-09