Recent developments in tandem mass spectrometry for lipidomic analysis

DOI	Resolve DOI: https://doi.org/10.1016/j.aca.2008.06.045
Author	Search for: Zehethofer, Nicole¹; Search for: Pinto, Devanand M.²
Name affiliation	National Research Council of Canada. NRC Institute for Marine Biosciences National Research Council of Canada. Human Health Therapeutics
Format	Text, Article
Journal title	Analytica Chimica Acta
Volume	627
Issue	3
Pages	62–70
Abstract	This review will focus on the role of mass spectrometry in the emerging field of lipidomics. Particular emphasis will be placed on recent developments in the use of tandem mass spectrometry methods in lipid analysis using low-energy collision induced dissociation (CID). After a brief discussion on ionization techniques, novel ion-activation methods that allow for increased sensitivity and selectivity will be critically discussed. Examples will be drawn from the analysis of higher order lipids, specifically triacylglycerols (TAGs) and glycerophospholipids, as the numerous positional isomers and head groups present in these classes of lipids continue to pose a significant analytical challenge to the field of lipidomics. The role of bioinformatics in the development of lipidomics will also be discussed
Publication date	2008-10-03
Publisher	Elsevier
Language	English
Peer reviewed	Yes
NRC number	NRCC 42784 1747
NPARC number	3538566
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Record identifier	e6a4da9a-c39f-42e4-9136-78becb732f48
Record created	2009-03-01
Record modified	2020-04-15