Recent developments in tandem mass spectrometry for lipidomic analysis

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1016/j.aca.2008.06.045
AuthorSearch for: 1; Search for: 2
Name affiliation
  1. National Research Council of Canada. NRC Institute for Marine Biosciences
  2. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
Abstract
This review will focus on the role of mass spectrometry in the emerging field of lipidomics. Particular emphasis will be placed on recent developments in the use of tandem mass spectrometry methods in lipid analysis using low-energy collision induced dissociation (CID). After a brief discussion on ionization techniques, novel ion-activation methods that allow for increased sensitivity and selectivity will be critically discussed. Examples will be drawn from the analysis of higher order lipids, specifically triacylglycerols (TAGs) and glycerophospholipids, as the numerous positional isomers and head groups present in these classes of lipids continue to pose a significant analytical challenge to the field of lipidomics. The role of bioinformatics in the development of lipidomics will also be discussed
Publication date
In
  • Analytica Chimica Acta 627, no. 3 (3 October 2008): 62–70.
LanguageEnglish
Peer reviewedYes
NRC numberNRCC 42784
1747
NPARC number3538566
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