Effects of neoplastic transformation and teniposide (VM26) on protein kinase C isoform expression in rodent fibroblasts

DOI	Resolve DOI: https://doi.org/10.1016/S0304-3835(99)00417-6
Author	Search for: Liu, Qing yan¹; Search for: Carson, Christine¹; Search for: Ribecco, Maria¹; Search for: Testolin, Lucia; Search for: Raptis, Leda; Search for: Walker, P.Roy¹; Search for: Sikorska, Marianna¹
Affiliation	National Research Council of Canada. NRC Institute for Biological Sciences
Format	Text, Article
Subject	middle T antigen; cell death; protein kinase C expression; proteolysis; F111; NIH3T3
Abstract	This study examined changes in protein kinase C (PKC) isoforms in rodent fibroblasts (rat F111 and mouse NIH3T3), transformed by the polyoma virus middle T antigen (mT) and undergoing apoptosis in response to teniposide (VM26). The mT-transformed cells up-regulated PKC δ and down-regulated both PKC ε and PKC λ expression, and were more sensitive to the drug than their non-transformed counterparts. The drug treatment further lowered the expression of PKC ε, triggered nuclear translocation of PKC δ and its site-specific proteolysis, consistent with the notion that changes in specific PKC isoforms play a role not only in the neoplastic transformation of fibroblasts, but also in their apoptotic response.
Publication date	2000-05
In	Cancer Letters 153, no. 1-2: 13–23.
Language	English
Peer reviewed	Yes
NPARC number	23001311
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Record identifier	e078849d-889f-4768-b286-356463d99adb
Record created	2017-01-17
Record modified	2020-03-26