Host resistance to intranasal Acinetobacter baumannii reinfection in mice

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1093/femspd/ftw048
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Name affiliation
  1. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
Journal titlePathogens and Disease
ISSN2049-632X
2049-632X
Volume74
Issue5
Article numberftw048
SubjectAcinetobacter baumannii; reinfection; host defense; pneumonia
Abstract
Acinetobacter baumannii is a major causative agent of healthcare-associated infection and develops multidrug resistance rapidly. However, little is known in the host defense mechanisms against this infection. In this study, we examined if mice recovered from a previous intranasal A. baumannii infection (recovered mice) are fully protected against a subsequent reinfection. We found that, despite the presence of specific serum IgG and mucosal IgA responses prior to the reinfection, the recovered mice were only marginally better protected against intranasal challenge with low doses of homologous or heterologous A. baumannii strains than the naïve mice. Post-challenge immune and inflammatory (cells and cytokines) responses were generally comparable between recovered and naïve mice although the recovered mice produced significantly higher amounts of IFN-γ and IL-17 and had higher percentages and numbers of resident lung CD44(hi)CD62L(-)CD4(+) and CD19(+) B lymphocytes. Taken together, our results suggest that mice recovered from a previous A. baumannii infection remain susceptible to reinfection, indicating the complexity of immune protection mechanism for this Gram-negative, multidrug-resistant emerging pathogen.
Publication date
PublisherOxford University Press
LanguageEnglish
Peer reviewedYes
NPARC number23001884
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Record created2017-05-05
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