| Download | - View final version: Coated silver nanoparticles exhibit unique stability and cytotoxicity in media with human serum (PDF, 934 KiB)
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| DOI | Resolve DOI: https://doi.org/10.31038/NAMS.2020325 |
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| Author | Search for: Kunc, Filip1; Search for: Kennedy, David C.1 |
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| Affiliation | - National Research Council of Canada. Metrology Research Centre
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| Format | Text, Article |
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| Physical description | 6 p. |
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| Subject | silver; nanoparticle; cytotoxicity; stability; spectroscopy |
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| Abstract | Commercially available silver nanoparticles with five different coatings were measured for stability in media supplemented with human serum (HS) to better mimic conditions that particles might be exposed to in biomedical applications. The particles were then tested for cytotoxicity and cellular uptake in two cell lines. The stability of the particles differs from what is observed in media supplemented with fetal bovine serum (FBS). There is also a change in both the cytotoxicity of the particles and their cellular uptake in hepatocytes and neurons. These changes show that the behaviour of particles in living organisms may differ considerably from what is observed in standard in vitro testing as the particles will behave differently in the different extracellular environment they are exposed to, highlighting one of the challenges of translating in vitro studies for nanoparticles to regulatory frameworks. |
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| Publication date | 2020-10-18 |
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| Publisher | Research Open World |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | d9c40c44-87c3-42f8-9588-af159fb86b0d |
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| Record created | 2020-11-16 |
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| Record modified | 2020-11-16 |
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