| DOI | Resolve DOI: https://doi.org/10.1016/j.peptides.2009.01.004 |
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| Author | Search for: Yang, Jun; Search for: Yang, Yu; Search for: Chu, Jiegen; Search for: Wang, Gen1; Search for: Xu, Hongtao; Search for: Liu, Wen-Yan; Search for: Wang, Cheng-Hai; Search for: Lin, Bao-Cheng |
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| Affiliation | - National Research Council of Canada. NRC Institute for Nutrisciences and Health
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| Format | Text, Article |
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| Subject | hypothalamic paraventricular nucleus; analgesia; endogenous opiate peptide; arginine vasopressin; spinal cord |
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| Abstract | Many studies have shown that hypothalamic paraventricular nucleus (PVN) plays a role in pain process, and endogenous opiate peptide system in the spinal cord is involved in nociception. This communication was designed to study the relationship between PVN and endogenous opiate system in the spinal cord in the rat. The results showed that in both the thoracic and the lumber spinal cord, microinjection of 100 ng l-glutamate sodium into PVN could increase leucine-enkephalin (L-Ek), β-endorphin (β-Ep), dynorphinA1–13 (DynA1–13) concentrations and PVN cauterization decreased L-Ek and β-Ep concentrations. Pretreatment of the spinal cord with 5 μg naloxone, an opiate receptor antagonist could partly reverse the analgesia induced by microinjection of 100 ng l-glutamate sodium into PVN. The data suggested that PVN analgesia might be involved in the endogenous opiate peptide system in the spinal cord independently. |
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| Publication date | 2009-01-15 |
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| Publisher | Elsevier |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 23004802 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | d64a3bc3-16a4-4250-a119-f45291fd063e |
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| Record created | 2018-12-20 |
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| Record modified | 2020-04-16 |
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