Electrical activity of artificial ion channels incorporated into planar lipid bilayers

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1039/A701060E
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FormatText, Article
Journal titleJournal of the Chemical Society, Perkin Transactions
Volume2
Issue8
Pages1469–1471
Subjectenvironmental
Abstract
The ion transport ability in a planar lipid bilayer of a 21 amino acid peptide bearing six 21-crown-7 side chains is reported. The compound was designed to form an artificial ion channel by stacking the crown rings, when adopting an á-helical conformation in a bilayer membrane. All the derivatives of 1 exhibited membrane conductivity with the best results obtained with the unprotected analog 4. The latter showed typical single channel activity.
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LanguageEnglish
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NRC number41770
NPARC number3539977
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Record identifierd0533652-a335-4f9a-b556-16442349996f
Record created2009-03-01
Record modified2020-03-20
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