Isolation and identification of (44-R,S)-44,55-dihydroxyyessotoxin from Protoceratium reticulatum, and its occurrence in extracts of shellfish from New Zealand, Norway and Canada

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1016/j.toxicon.2005.03.007
Author	Search for: Finch, Sarah C.; Search for: Wilkins, Alistair L.; Search for: Hawkes, Allan D.; Search for: Jensen, Dwayne J.; Search for: MacKenzie, A. Lincoln; Search for: Beuzenberg, Veronica; Search for: Quilliam, Michael A.¹; Search for: Olsen, Christine D.; Search for: Samdal, Ingunn A.; Search for: Aasen, John; Search for: Selwood, Andrew I.; Search for: Cooney, Janine M.; Search for: Sandvik, Morten; Search for: Miles, Christopher O.
Affiliation	National Research Council of Canada. Measurement Science and Standards
Format	Text, Article
Subject	animal physiology; marine molluscs; mass spectroscopy; molecular structure; N.M.R.; shellfish; toxicity; Protoceratium reticulatum
Abstract	44,55-Dihydroxyyessotoxin (1) was isolated from extracts of Protoceratium reticulatum and identified by analysis of its one- and two-dimensional NMR and mass spectra. In addition, LC–MS methods revealed the presence of compounds tentatively identified as (44-R,S)-44,55-dihydroxy-41a-homoyessotoxin (2) and (44-R,S)-44,55-dihydroxy-9-methyl-41a-homoyessotoxin (3). LC–MS analyses indicate that 1 is a constituent of P. reticulatum in New Zealand and Norway, and it was present in three species of mussels from New Zealand, Norway, and Canada.
Publication date	2005-08
Terms of use	Copyright © 2005 Elsevier Ltd All rights reserved.
In	Toxicon 46, no. 2 (August 2005): 160–170.
Language	English
Peer reviewed	Yes
NRC number	1661
NPARC number	3538353
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Record identifier	cc07b62c-24ae-486c-bc8c-57423d7a498f
Record created	2009-03-01
Record modified	2020-04-07

Date modified:: 2024-12-21