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Animal models

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DOIResolve DOI: https://doi.org/10.1258/0007142001903238
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FormatText, Article
Subjectacute cerebrovascular accidents; cerebrovascular accident; cerebral ischemia; lacunar infarction; ischemic stroke; animal model
Abstract
Animal models of cerebral ischaemia mimic at best less than 25% od all strokes. Compounds which prove efficacious in animal models should, therefore, only be expected to imporve outcome in a quarter of all strokes. If trials for acute stroke are to succeed, stroke subgroups represented by the animal models should be targeted. For the other subgroups, e.g. lacunar stroke, appropriate animal models need to be deveoloped. Moreover, throbolysis should be included in animal models because it is likely to be used as a first line treatment for ischaemic stroke and any future therapeutics with need to be compatible with it.
Publication date
PublisherOxford University Press
In
  • British Medical Bulletin 56, no. 2: 307–317.
LanguageEnglish
Peer reviewedYes
NPARC number9367434
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Record identifierc409218f-0d0c-4413-8f66-15add90014fe
Record created2009-07-10
Record modified2020-05-27
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