Deconvolution of isobaric interferences in mass spectra

DOI	Resolve DOI: https://doi.org/10.1016/j.jasms.2003.12.016
Author	Search for: Meija, Juris ORCID identifier: https://orcid.org/0000-0002-3349-5535; Search for: Caruso, Joseph A.
Format	Text
Type	Article
Journal title	Journal of the American Society for Mass Spectrometry
ISSN	1044-0305 1879-1123
Volume	15
Issue	5
Pages	654–658
Abstract	The concept of isobar deconvolution using the mass domain and signal intensity based domains is described. The intensity domain-based approach employs the reconstruction of the observed isotope pattern from the isolated patterns of the isobaric species. The quantitative information is adjusted with the use of the least squares algorithm. The mass domain-based approach employs signal deconvolution by forming Gaussian components for which the peak width and position can be predicted a priori. The latter method is applicable to medium resolution instruments, such as TOF-MS, while the pattern reconstruction approach is applicable also to low resolution instrumentation, such as quadrupole-based ICP-MS or GC/MS. An example of CHzSe (z = 0–4) cluster analysis in dimethyl diselenide mass spectra is given to illustrate the concepts underlying both approaches.
Publication date	2004-02-27
Publisher	Springer
Language	English
Peer reviewed	Yes
NPARC number	23001629
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Record identifier	bf75f7e9-b8e4-4cd5-a7ce-f05462f2a2e7
Record created	2017-03-13
Record modified	2020-04-03