Advances in radical-trapping antioxidant chemistry in the 21st century: A kinetics and mechanisms perspective

From National Research Council Canada

Download	View accepted manuscript: Advances in radical-trapping antioxidant chemistry in the 21st century: A kinetics and mechanisms perspective (PDF, 1 MB)
DOI	Resolve DOI: https://doi.org/10.1021/cr500226n
Author	Search for: Ingold, Keith U.¹; Search for: Pratt, Derek A.
Name affiliation	National Research Council of Canada. Security and Disruptive Technologies
Format	Text, Article
Subject	Industrial research; Structural optimization; 20th century; Anti-oxidant chemistry; Commercial perspectives; Degenerative disease; Kinetics and mechanism; Optimal performance; Radical trapping; Synergistic interaction; Antioxidants
Abstract	Antioxidants were divided in two parts radical-trapping antioxidants (RTAs) and preventive antioxidants. By the final quarter of the 20th century, the commercial importance of antioxidants was overshadowed by their putative role in human health, as the implication of radical-mediated oxidation in virtually all types of degenerative diseases, including cancer and aging, emerged. From a commercial perspective, there continues to be significant interest in the development of RTA technology. Much of the industrial research effort has been on optimization of the structures of existing RTAs to provide appropriate physical properties and identification of combinations of existing RTAs that achieve optimal performance via the synergistic interactions.
Publication date	2014-09-02
In	Chemical Reviews 114, no. 18 (September 2, 2014): 9022–9046.
Language	English
Peer reviewed	Yes
NPARC number	21275468
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Record identifier	be52eb53-3488-492c-8d10-f6d56d0a36e5
Record created	2015-07-14
Record modified	2020-06-04

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Date modified:: 2021-07-26