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Blood–brain barrier models : in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1517/17460441.2015.974545
AuthorSearch for: 1; Search for: 2; Search for: 2; Search for: 1
Affiliation
  1. National Research Council of Canada. Human Health Therapeutics
  2. National Research Council of Canada
FormatText, Article
Subjectbiomarkers; blood–brain barrier; in vitro blood–brain barrier models; stem cells
Abstract
The majority of therapeutics, small molecule or biologics, developed for the CNS do not penetrate the blood–brain barrier (BBB) sufficiently to induce pharmacologically meaningful effects on CNS targets. To improve the efficiency of CNS drug discovery, several in vitro models of the BBB have been used to aid early selection of molecules with CNS exposure potential. However, correlative studies suggest relatively poor predictability of in vitro BBB models underscoring the need to combine in vitro and in vivo BBB penetration assessment into an integrated preclinical workflow.
Publication date
In
  • Expert Opinion on Drug Discovery 10, no. 2 (12 November 2014): 141–155.
LanguageEnglish
Peer reviewedYes
NRC numberNRC-HHT-53275
NPARC number21275154
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Record identifierba8b53a4-5b2c-4342-bb48-92ee7f85c7c1
Record created2015-05-21
Record modified2020-04-22
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