Synthesis, metabolism and biological activity of a deuterated analogue of the plant hormone S-(+)-abscisic acid

From National Research Council Canada

DOI	Resolve DOI: https://doi.org/10.1016/0031-9422(95)00581-1
Author	Search for: Lamb, N.¹; Search for: Wahab, N.¹; Search for: Rose, P.A.¹; Search for: Shaw, A.C.¹; Search for: Abrams, S.R.¹; Search for: Cutler, A.J.¹; Search for: Smith, P.J.; Search for: Gusta, L.V.; Search for: Ewan, B.
Affiliation	National Research Council of Canada. NRC Plant Biotechnology Institute
Format	Text, Article
Subject	abscisic acid; ABA; phaseic acid; deuterium labelled analogue; synthesis; metabolism; isotope effect; germination inhibition; Zea mays; Lepidium sativum; gramineae; cruciferae
Abstract	The synthesis of a deuterated analogue of the plant hormone S-(+)-abscisic acid (ABA), S-(+)-[7′, 7′, 7′, 8′, 8′, 8′, 9′, 9′, 9′]-nonadeuteroabscisic acid [(+)-d₉-ABA], is described. The biological activity of (+)-d₉-ABA was compared to that of (+)-ABA in two assays. Analogous to the metabolism of (+)-ABA to (−)-phaseic acid (PA) by maize (Zea mays L. cv Black Mexican Sweet) cell suspension cultures, (+)-d₉-ABA was oxidized but at a slower rate to d₈-PA at 25°. At low concentrations the deuterated analogue was a more effective inhibitor of cress seed (Lepidium sativum L.) germination than the natural hormone.
Publication date	1996-01
Publisher	Elsevier
In	Phytochemistry 41, no. 1 (January 1996): 23–28.
Language	English
Peer reviewed	Yes
Identifier	0031942295005811 NRCC-38922
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Record identifier	b9a7a345-a8e7-4c38-9e5a-46900971dccf
Record created	2023-11-02
Record modified	2023-11-02

Date modified:: 2025-06-15