| DOI | Resolve DOI: https://doi.org/10.1074/jbc.M113.505917 |
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| Author | Search for: Murase, T.; Search for: Eugenio, L.; Search for: Schorr, M.; Search for: Hussack, G.1; Search for: Tanha, J.1; Search for: Kitova, E.N.; Search for: Klassen, J.S.; Search for: Ng, K.K.S. |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Abstract | Background: TcdA and TcdB are the main virulence factors for Clostridium difficile infections. Results: X-ray crystallography, mass spectrometry, and size exclusion chromatography reveal the molecular basis of antibody recognition. Conclusion: Neutralizing antibodies do not directly block binding to known receptors, suggesting new mechanisms of neutralization. Significance: The molecular details of antibody recognition will assist with the development of novel therapeutics and diagnostics. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. |
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| Publication date | 2014 |
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| Publisher | American Society for Biochemistry and Molecular Biology |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21270832 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | b7672678-50a3-4cef-8022-8a23ad9d4bdf |
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| Record created | 2014-02-17 |
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| Record modified | 2020-04-22 |
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