| Download | - View accepted manuscript: Surface modification of nonviral nanocarriers for enhanced gene delivery (PDF, 2.9 MiB)
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| DOI | Resolve DOI: https://doi.org/10.2217/nnm.13.194 |
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| Author | Search for: Fortier, Charles1; Search for: Durocher, Yves1; Search for: De Crescenzo, Gregory1 |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | biofunctionalization; lateral stabilization; nonviral gene delivery; polymeric coating; responsive teethering; shielding; surface modification |
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| Abstract | Biomedical nanotechnology has given a new lease of life to gene therapy with the ever-developing and ever-diversifying nonviral gene delivery nanocarriers. These are designed to pass a series of barriers in order to bring their nucleic acid cargo to the right subcellular location of particular cells. For a given application, each barrier has its dedicated strategy, which translates into a physicochemical, biological and temporal identity of the nanocarrier surface. Different strategies have thus been explored to implement adequate surface identities on nanocarriers over time for systemic delivery. In that context, this review will mainly focus on organic nanocarriers, for which these strategies will be described and discussed. |
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| Publication date | 2014-01-01 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NRC number | NRC-HHT-53218 |
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| NPARC number | 21272291 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | b2090f29-f135-4bef-a18b-096bec9ad146 |
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| Record created | 2014-07-23 |
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| Record modified | 2020-06-04 |
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