Quantitative MRI reveals the elderly ischemic brain is susceptible to increased early blood-brain barrier permeability following tissue plasminogen activator related to claudin 5 and occludin disassembly

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1038/jcbfm.2011.79
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Name affiliation
  1. National Research Council Canada. NRC Institute for Biodiagnostics
Journal titleJournal of Cerebral Blood Flow and Metabolism
Pages18741885; # of pages: 12
Subjectalteplase; claudin 5; gadolinium pentetate; occludin; age distribution; aged; aging; animal experiment; animal model; blood brain barrier; brain hematoma; brain ischemia; disease exacerbation; drug megadose; male; middle cerebral artery occlusion; nuclear magnetic resonance imaging; protein assembly; protein phosphorylation; rat; reperfusion injury; Age Factors; Aging; Blood-Brain Barrier; Brain; Brain Ischemia; Fibrinolytic Agents; Infarction, Middle Cerebral Artery; Magnetic Resonance Imaging; Male; Membrane Proteins; Permeability; Rats; Rats, Wistar; Tissue Plasminogen Activator
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Peer reviewedYes
NPARC number21271111
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Record identifierae12c4a7-5885-474d-9f42-8acdfa74a406
Record created2014-03-24
Record modified2019-08-20
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