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The relation of three-dimensional structure to biosynthesis in the N-linked oligosaccharides

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1139/o83-135
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FormatText, Article
Subjectalpha; biosynthesis; calculation; carbohydrate conformation; crystal; crystal-structure; energy; energy calculations; enzyme; magnetic resonance spectroscopy; magnetic-resonance; N-linked; nuclear; nuclear magnetic resonance; oligosaccharide; orientation; pathway; potential; resonance; series; specificity; structural; structure; substrate specificity
Abstract
The three-dimensional structures are presented for representative N-linked oligosaccharides drawn from four major structural classes. The nuclear magnetic resonance evidence leading to these structures is summarized and the conclusions are compared with those obtained from potential energy calculations and from the crystal structures of fragments. The major finding is that the Man α 1-3 arm structure is invariant throughout the series, whereas the Man α 1-6 arm has two possible orientations in some structures and a single orientation in others. Finally, the three-dimensional structures permit a rationalization of the substrate specificity of several key enzymes in the biosynthetic pathway
Publication date
PublisherCanadian Science Publishing
In
  • Canadian Journal of Biochemistry and Cell Biology 61, no. 9: 1067–1078.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

IdentifierNRC-IBS-BRISSON1983F
NPARC number9358703
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Record identifierace11c78-ec34-40d7-b30a-157de773aee3
Record created2009-07-10
Record modified2020-03-13
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