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Capsular polysaccharide structure of Acinetobacter baumannii K58 from clinical isolate MRSN31468

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DOIResolve DOI: https://doi.org/10.1016/j.carres.2024.109307
AuthorSearch for: 1ORCID identifier: https://orcid.org/0000-0002-8723-3311; Search for: 1ORCID identifier: https://orcid.org/0000-0002-5364-1376; Search for: 1; Search for: 1; Search for: ; Search for: ; Search for: 1; Search for: 1; Search for: 1ORCID identifier: https://orcid.org/0000-0003-0958-7728; Search for: 1ORCID identifier: https://orcid.org/0000-0003-0176-9463
Affiliation
  1. National Research Council of Canada. Human Health Therapeutics
FormatText, Article
SubjectA. baumannii; K58; capsular polysaccharide; phage; depolymerase
Abstract
Capsular polysaccharides (CPS) of Acinetobacter baumannii is a virulence factor with diverse structures. CPS are produced by the CPS biosynthesis gene cluster in their K locus (KL). However, CPS variations may occur due to insertion of additional genes from external sources, e.g., prophages. Recently, the CPS structure from a clinical isolate, BAL062 which includes KL58 locus, was found to have a pseudaminic acid isomer (8ePse5NAc7NAc) as a result of prophage inserted epaA/epaB genes. Here, we report a CPS structure produced by A. baumannii strain MRSN31468 which also belongs to a KL58 type. The K58 CPS structure was determined by 1D and 2D NMR analysis of the oligosaccharides derived from the CPS by a phage depolymerase, and supported by the sugar composition analysis. The K58 CPS structure has the following tetra saccharide repeating unit.
Publication date
PublisherElsevier
In
  • Carbohydrate Research 546, no. C, 109307 (December 2024).
LanguageEnglish
Peer reviewedYes
IdentifierS0008621524002866
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Record identifierac498dbf-d373-4a8f-bd8f-e650d0e5d3ac
Record created2024-12-09
Record modified2025-04-30
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