Influence of circulating cytokines on prolactin during slow vs. fast exertional heat stress followed by active or passive recovery

From National Research Council Canada

Download
  1. (PDF, 918 KB)
DOIResolve DOI: https://doi.org/10.1152/japplphysiol.00523.2012
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for:
FormatText
TypeArticle
Journal titleJournal of Applied Physiology
ISSN8750-7587
1522-1601
Volume113
Issue4
Pages574–583
Subjectneuroimmune response; core temperature; peripheral fatigue marker; serotonin and dopamine interplay
Abstract
Prolactin (PRL) has been suggested as an indicator of fatigue during exertional heat stress (EHS), given its strong relationship with body core temperature (Tc); however, the strength of this relationship during different rates of Tc increase and subsequent recovery is unknown. In addition, given the influence that systemic cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, have on the pituitary gland, it would be of interest to determine the relationship between PRL, IL-6, and TNF-α during EHS. The purpose was to examine the PRL, IL-6, and TNF-α heat stress responses during slow and fast heating and subsequent resting or cold water immersion recovery. On 4 days, nine individuals walked at ∼45% (slow heating) or ran at ∼65% (fast heating) maximal oxygen consumption on a treadmill in the heat (40°C, 30% relative humidity) until rectal temperature (Tre) reached 39.5°C (esophageal temperature; fast = 39.41 ± 0.04°C, slow = 39.82 ± 0.09°C). Post-EHS, subjects were either immersed in 2°C water or rested seated until Tre returned to 38.0°C. Venous blood, analyzed for PRL, IL-6, and TNF-α, was obtained at rest, during exercise (Tre 38.0, 39.0, 39.5°C), the start of recovery (∼5 min after 39.5°C), and subsequent recovery (Tre 39.0, 38.0°C). IL-6 exhibited myokine properties, given the greater increases with slow heating and lack of increase in TNF-α. A strong temperature-dependent PRL response during slow and fast heating provides additional support for the use of PRL as a peripheral marker of impending fatigue, which is independent of IL-6 and TNF-α cytokine responses.
Publication date
PublisherAmerican Physical Society
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number23001225
Export citationExport as RIS
Report a correctionReport a correction
Record identifieraac8e376-676b-4dcf-b742-1efc65ba60aa
Record created2017-01-06
Record modified2020-02-06
Report a problem on this page
Date modified: