| DOI | Resolve DOI: https://doi.org/10.1093/glycob/cwv037 |
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| Author | Search for: Haji-Ghassemi, O.; Search for: Blackler, R.J.; Search for: Young, N.M.1; Search for: Evans, S.V. |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Subject | anti-carbohydrate antibodies; carbohydrate recognition; Chlamydia; HIV-1 gp120; lipopolysaccharide; monoclonal antibody; X-ray crystal structures |
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| Abstract | Carbohydrate antigens are valuable as components of vaccines for bacterial infectious agents and human immunodeficiency virus (HIV), and for generating immunotherapeutics against cancer. The crystal structures of anti-carbohydrate antibodies in complex with antigen reveal the key features of antigen recognition and provide information that can guide the design of vaccines, particularly synthetic ones. This review summarizes structural features of anti-carbohydrate antibodies to over 20 antigens, based on six categories of glyco-antigen: (i) the glycan shield of HIV glycoproteins; (ii) tumor epitopes; (iii) glycolipids and blood group A antigen; (iv) internal epitopes of bacterial lipopolysaccharides; (v) terminal epitopes on polysaccharides and oligosaccharides, including a group of antibodies to Kdo-containing Chlamydia epitopes; and (vi) linear homopolysaccharides. |
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| Publication date | 2015 |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| NPARC number | 21277037 |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 9f334212-7476-4082-a512-7812740f9d70 |
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| Record created | 2015-11-10 |
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| Record modified | 2020-04-22 |
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