Chemical constituents of Brazilian propolis and their cytotoxic activities

From National Research Council Canada

DOIResolve DOI: https://doi.org/10.1021/np980028c
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FormatText, Article
Abstract
The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2,2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds, 2−23. Of the known compounds, 4, 7, 12−19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propolis, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19−21 showed potent cytotoxicity, having ED50 values equal to or less than 10 μg/mL.
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In
  • Journal of Natural Products 61, no. 7 (12 June 1998): 896–900.
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21275308
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