| Download | - View final version: 2′-Fluoro-c-di-GMP as an oral vaccine adjuvant (PDF, 865 KiB)
- View supplementary information: 2′-Fluoro-c-di-GMP as an oral vaccine adjuvant (PDF, 945 KiB)
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| DOI | Resolve DOI: https://doi.org/10.1039/C9RA08310C |
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| Author | Search for: Li, Jia; Search for: Lee, Rhonda Kuo1; Search for: Chen, Wangxue1; Search for: Yan, HongbinORCID identifier: https://orcid.org/0000-0002-9087-0493 |
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| Affiliation | - National Research Council of Canada. Human Health Therapeutics
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| Format | Text, Article |
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| Abstract | Bis-(3′–5′)-cyclic dimeric 2′-deoxy-2′-fluoroguanosine monophosphate (2′-F-c-di-GMP) was synthesized through the modified H-phosphonate chemistry. Oral immunization of C57BL/6 mice with Helicobacter pylori cell-free sonicate extract adjuvanted with 2′-F-c-di-GMP led to the production of antigen-specific antibodies in feces and sera, and lowered bacterial counts in the stomach upon post-vaccination infections in immunized mice. Similarly, oral vaccination of BALB/c mice with flagillin proteins from Clostridium difficile and Listeria monocytogenes adjuvanted with 2′-F-c-di-GMP led to production of antigen-specific antibodies both systemically and mucosally. The adjuvanticity of 2′-F-c-di-GMP is associated with the enhanced induction of interferon γ. These results demonstrated the excellent oral adjuvanticity of 2′-F-c-di-GMP. |
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| Publication date | 2019-12-16 |
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| Publisher | Royal Society of Chemistry |
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| Licence | |
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| In | |
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| Language | English |
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| Peer reviewed | Yes |
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| Export citation | Export as RIS |
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| Report a correction | Report a correction (opens in a new tab) |
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| Record identifier | 94a66d90-ff56-4295-987b-7da2daaef0ac |
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| Record created | 2020-11-06 |
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| Record modified | 2020-11-09 |
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